[Fisher syndrome with optic neuropathy].

Abstract

UNLABELLED:

Fisher syndrome with optic neuropathy has been rarely reported. We report a 78-year-old Frenchman with Fisher syndrome. The patient complained of dizziness and bilateral blurred vision. His corrected visual acuity was 0.03 in the right eye, and 0.02 in the left eye. Deep tendon reflexes were absent. A few days later, bilateral complete external ophthalmoplegia appeared. Both pupils were dilated and pupillary reflexes were absent. Serum anti-GQlb antibodies and anti-GT1a antibodies were detected. After intravenous immunoglobulin treatments, all neurological symptoms including optic neuropathy and external ophthalmoplegia disappered except for pupillary dilatation associated with light-near dissociation. Tonic pupil indicated disorder of the peripheral nervous system.

CONCLUSION:

Fisher syndrome may complicate optic neuropathy.

• Authors: Noriko Koga, Hiroshi Ishikawa, Yuu Itou, Masayuki Minami, Tomohiko Mizutani
• Journal: Nippon Ganka Gakkai zasshi (Nippon Ganka Gakkai Zasshi) Vol. 112 Issue 9 Pg. 801-5 (Sep 2008) ISSN: 0029-0203 [Print] Japan
• PMID: 18833944 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Biomarkers
• Gangliosides
• Immunoglobulin G
• Immunoglobulins, Intravenous
• GQ1b ganglioside

Topics

• Aged
• Biomarkers (blood)
• Gangliosides (immunology)
• Humans
• Immunoglobulin G (blood)
• Immunoglobulins, Intravenous (therapeutic use)
• Male
• Miller Fisher Syndrome (complications, diagnosis, drug therapy)
• Optic Nerve Diseases (complications, diagnosis, drug therapy)
• Treatment Outcome