[Comparative efficacy of different muscle relaxants in the rehabilitation of post-stroke patients with spasticity].

Abstract

An influence of different muscle relaxants on muscle tone and functional rehabilitation has been studied in 360 post-stroke patients. Muscle tone has been assessed with the Ashworth scale and functional rehabilitation with Barthel, Lindmark and Scandinavian scales as well as the Merton & Sutton scale. Efficacy of muscle relaxants has been assessed by the 2 min. walking test. Moreover, we suggested a coefficient for calculating drug efficacy. The results of the study revealed that tolperisone was the most efficient in the treatment of post-stroke patients with spasticity. Tizanidine was also effective but to a lesser extent. Other drugs studied did not reveal any significant effect. Tolperisone had a good tolerability, the adverse effects in patients treated with this drug were registered more rarely compared to other ones.

• Authors: V V Koval'chuk, A A Skoromets, I V Vasil'eva
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 108 Issue 8 Pg. 14-9 ( 2008) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 18833102 (Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Muscle Relaxants, Central

Topics

• Adult
• Aged
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Muscle Relaxants, Central (therapeutic use)
• Muscle Spasticity (drug therapy, etiology)
• Stroke (complications)