Abstract | OBJECTIVE: In polycystic ovary syndrome (PCOS), insulin resistance (IR) appears with high prevalence and represents the major cause of cardiometabolic complications. Lipin 1beta regulates lipid metabolism and augments insulin sensitivity. The impact of lipin 1beta expression in visceral and subcutaneous adipose tissue of PCOS patients on IR was studied for the first time. METHODS: RESULTS: In PCOS patients, lipin 1beta expression in both adipose depots was lower than in controls: 0.76 (0.67-0.84) vs 1.16 (0.90-1.43) for visceral and 0.91 (0.73-1.10) vs 1.30 (1.03-1.57) for s.c. depot (both P<10(-4)). The difference remained significant after adjustment for body mass index (BMI) and also when comparing only lean patients with lean controls. In PCOS patients, visceral adipose lipin 1beta expression correlated negatively with homeostasis model assessment-IR (r=-0.474, P=0.017), BMI (r=-0.511, P=0.009) and waist circumference (r=-0.473, P=0.017), waist circumference remaining significant (P=0.027) in multiple regression. Subcutaneous lipin 1beta expression in PCOS correlated negatively with BMI, waist circumference and plasma triglycerides, and positively with high density lipoprotein-cholesterol. Subcutaneous, but not visceral lipin 1beta expression, correlated positively with the studied genes. CONCLUSIONS:
Lipin 1beta appears to be involved in the pathogenesis of IR in PCOS.
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Authors | Barbara Mlinar, Marija Pfeifer, Eda Vrtacnik-Bokal, Mojca Jensterle, Janja Marc |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 159
Issue 6
Pg. 833-9
(Dec 2008)
ISSN: 1479-683X [Electronic] England |
PMID | 18829900
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nuclear Proteins
- LPIN1 protein, human
- Phosphatidate Phosphatase
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Topics |
- Adult
- Female
- Gene Expression Regulation
(physiology)
- Humans
- Insulin Resistance
(physiology)
- Intra-Abdominal Fat
(physiology)
- Nuclear Proteins
(antagonists & inhibitors, biosynthesis, genetics)
- Phosphatidate Phosphatase
- Polycystic Ovary Syndrome
(genetics, metabolism)
- Young Adult
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