| Abstract | In a double-blind, randomized study, we compared the healing of gastric ulcer during a twice-daily regimen of 2 g sucralfate or sucralfate 1 g q.i.d. Patients receiving the former therapy received the tablets one-half hour before breakfast and at bedtime. Patients receiving sucralfate 1 g q.i.d. received their therapy 30 minutes before breakfast, lunch, and supper, and at bedtime. The study included 52 patients with endoscopically proven gastric ulcer; 41 patients completed the study. Healing was endoscopically assessed at 8 weeks and 12 weeks. After 8 and 12 weeks the healing rate for sucralfate 2 g b.i.d. was 67% and 92%, respectively; the healing rate of sucralfate 1 g q.i.d. was 59% and 71%, respectively. No statistically significant difference was found between the two regimens. The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 1 g sucralfate q.i.d. |
| Authors | A E Simjee, K E Pettengell, J M Spitaels
(Affiliation: Department of Medicine, University of Natal/King Edward VIII Hospital, Congella, Durban, South Africa.)
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| Journal | The American journal of medicine
(Am J Med)
Vol. 91
Issue 2A
Pg. 68S-70S
(Aug 8 1991)
ISSN: 0002-9343 UNITED STATES |
| PMID | 1882907
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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| Chemical References |
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| Topics |
- Adult
- Aged
- Ambulatory Care
- Double-Blind Method
- Endoscopy, Gastrointestinal
- Female
- Humans
- Male
- Middle Aged
- Patient Compliance
- Prospective Studies
- Stomach Ulcer
(diagnosis, drug therapy, psychology)
- Sucralfate
(administration & dosage, pharmacology, therapeutic use)
- Wound Healing
(drug effects)
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