Abstract | OBJECTIVE: DESIGN: SETTING: University hospital laboratory. SUBJECTS: Male rats. INTERVENTIONS:
Hemorrhagic shock was induced by withdrawing blood to a mean arterial pressure of 50 mm Hg. At 3 hrs after hemorrhage, rats were rapidly resuscitated by returning their shed blood. At the time of resuscitation and every hour thereafter, animals received ciglitazone (10 mg/kg) or vehicle intraperitoneally. Heart rate and mean arterial pressure were measured throughout the experiment. Plasma and lung tissue were collected for analysis up to 3 hrs after resuscitation. MEASUREMENTS AND MAIN RESULTS: CONCLUSION:
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Authors | Ranjit S Chima, Paul W Hake, Giovanna Piraino, Prajakta Mangeshkar, Alvin Denenberg, Basilia Zingarelli |
Journal | Critical care medicine
(Crit Care Med)
Vol. 36
Issue 10
Pg. 2849-57
(Oct 2008)
ISSN: 1530-0293 [Electronic] United States |
PMID | 18828195
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Blood Glucose
- Chemokines
- Cytokines
- Inflammation Mediators
- NF-kappa B
- PPAR gamma
- Thiazolidinediones
- Peroxidase
- ciglitazone
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Topics |
- Animals
- Blood Glucose
(analysis)
- Chemokines
(blood)
- Cytokines
(blood)
- Disease Models, Animal
- Immunohistochemistry
- Inflammation Mediators
(blood)
- Infusions, Parenteral
- Male
- Metabolic Networks and Pathways
(drug effects)
- NF-kappa B
(antagonists & inhibitors, metabolism)
- PPAR gamma
(antagonists & inhibitors, metabolism)
- Peroxidase
(blood)
- Pneumonia
(pathology, prevention & control)
- Probability
- Random Allocation
- Rats
- Rats, Wistar
- Resuscitation
(methods)
- Sensitivity and Specificity
- Shock, Hemorrhagic
(drug therapy, metabolism)
- Thiazolidinediones
(pharmacology)
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