[Phosphocreatine, tocopheryl phosphate and their combination in acute ischemia and myocardial reperfusion in dogs: the effect on rhythm disorders, left ventricle contractility and infarct size].

Abstract

The effects of phosphocreatine and tocopheryl phosphate and their combined use in ischemia and reperfusion of the heart were studied in anesthetized dogs. The investigation focused on the size of myocardial infarction and left ventricular contractility, ischemic and reperfusion arrhythmias were assessed using Holter monitoring. Phosphocreatine was found to reduce the number of arrhythmias and to prevent the fatal outcomes in myocardial ischemia animals but not to influence the reperfusion rhythm disturbances. Combined administration of tocopheryl phosphate and phosphocreatine, in contrast to their isolated use, completely prevented the development of ventricular fibrillations and fatal outcomes in the animals with reconstructed coronary flow. Administration of phosphocreatine restricted the infarction size, combined use of the drugs facilitated its further reduction, while the group with isolated administration of tocopheryl phosphate showed the infarction size to differ insignificantly from the control values. Combined administration of the drugs, unlike their use alone, improved left ventricular contractility in reperfusion of ischemic myocardium. The cardioprotective effect observed in combined administration of the drugs was attended with depressed lipid peroxidation in reperfused myocardium.

• Authors: E A Konorev, V A Saks, D V Rudnev, L A Konorev, V G Sharov, V E Kagan, V V Pichugin, R P Evstigneeva
• Journal: Vestnik Akademii meditsinskikh nauk SSSR (Vestn Akad Med Nauk SSSR) Issue 3 Pg. 35-9 ( 1991) ISSN: 0002-3027 [Print] Russia (Federation)
• Vernacular Title: Fosfokreatin, tokoferilfosfat i ikh sochetanie pri ostroĭ ishemii i reperfuzii miokarda u sobak: vliianie na narusheniia ritma, levozheludochkovuiu sokratimost' i razmer infarkta.
• PMID: 1882538 (Publication Type: English Abstract, Journal Article)

Chemical References

• Phosphocreatine
• Vitamin E
• alpha-tocopherol phosphate
• alpha-Tocopherol

Topics

• Animals
• Arrhythmias, Cardiac (drug therapy)
• Dogs
• Drug Therapy, Combination
• Myocardial Contraction (drug effects)
• Myocardial Infarction (pathology, surgery)
• Myocardial Reperfusion Injury (drug therapy)
• Phosphocreatine (administration & dosage, therapeutic use)
• Ventricular Function, Left (drug effects)
• Vitamin E (administration & dosage, analogs & derivatives, therapeutic use)
• alpha-Tocopherol (analogs & derivatives)