| Abstract | We describe a case of pediatric Wegener granulomatosis initially treated with cyclophosphamide and oral corticosteroids resulting in remission for 5 years. Of note in this case is relapse with severe pulmonary disease treated with multiple regimens, all unsuccessful. Patient achieved remission with rituximab infusion therapy. This demonstrates how rituximab may be beneficial for childhood-onset Wegener granulomatosis unresponsive to conventional therapy. The case is followed by a review of the current treatment options. |
| Authors | Aarat M Patel, Thomas J A Lehman
(Affiliation: Department of Medicine/Pediatrics, Stony Brook University Medical Center, Stony Brook, NY, USA. aarat.patel at chp.edu)
|
| Journal | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
(J Clin Rheumatol)
Vol. 14
Issue 5
Pg. 278-80
(Oct 2008)
ISSN: 1536-7355 United States |
| PMID | 18824926
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Antibodies, Monoclonal
- Immunologic Factors
- Immunosuppressive Agents
- rituximab
- Cyclophosphamide
- Prednisolone
|
| Topics |
- Adolescent
- Antibodies, Monoclonal
(administration & dosage, therapeutic use)
- Cyclophosphamide
(administration & dosage)
- Disease Progression
- Glomerular Filtration Rate
- Humans
- Immunologic Factors
(administration & dosage, therapeutic use)
- Immunosuppressive Agents
(administration & dosage)
- Male
- Prednisolone
(administration & dosage)
- Tomography, X-Ray Computed
- Wegener Granulomatosis
(diagnosis, drug therapy, physiopathology, radiography)
|
