Abstract |
Congenital dyserythropoietic anemia (CDA) is a rare group of red blood cell disorders characterized by ineffective erythropoiesis and increased iron absorption. To determine whether growth differentation factor 15 (GDF15) hyper-expression is associated with the ineffective erythropoiesis and iron-loading complications of CDA type I (CDA I), GDF15 levels and other markers of erythropoiesis and iron overload were studied in blood from 17 CDA I patients. Significantly higher levels of GDF15 were detected among the CDA I patients (10 239 +/- 3049 pg/mL) compared with healthy volunteers (269 +/- 238 pg/mL). In addition, GDF15 correlated significantly with several erythropoietic and iron parameters including Hepcidin-25, Ferritin, and Hepcidin-25/ Ferritin ratios. These novel results suggest that CDA I patients express very high levels of serum GDF15, and that GDF15 contributes to the inappropriate suppression of hepcidin with subsequent secondary hemochromatosis.
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Authors | Hannah Tamary, Hanna Shalev, Galit Perez-Avraham, Meira Zoldan, Itai Levi, Dorine W Swinkels, Toshihiko Tanno, Jeffery L Miller |
Journal | Blood
(Blood)
Vol. 112
Issue 13
Pg. 5241-4
(Dec 15 2008)
ISSN: 1528-0020 [Electronic] United States |
PMID | 18824595
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Chemical References |
- Antimicrobial Cationic Peptides
- Biomarkers
- Growth Differentiation Factor 15
- HAMP protein, human
- Hepcidins
- Ferritins
- Iron
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Topics |
- Anemia, Dyserythropoietic, Congenital
(etiology)
- Antimicrobial Cationic Peptides
(blood)
- Biomarkers
(blood)
- Case-Control Studies
- Erythropoiesis
- Female
- Ferritins
(blood)
- Growth Differentiation Factor 15
(blood)
- Hepcidins
- Humans
- Iron
(metabolism)
- Iron Overload
- Israel
- Male
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