[WHO classification of tumours of the CNS: revised edition of 2007 with critical comments on the typing und grading of common-type diffuse gliomas].

Abstract

The fourth edition of the WHO classification of tumours of the CNS was published in 2007. Six new entities were codified: angiocentric glioma (AG); papillary glioneuronal tumour (PGNT); rosette-forming glioneuronal tumour of the fourth ventricle (RGNT); papillary tumour of the pineal region (PTPR); spindle cell oncocytoma of the adenohypophysis (SCO); and pituicytoma. Furthermore, six histological variants of well-known brain tumours have been added, partially because they show different biological behaviour and/or prognosis: pilomyxoid astrocytoma; atypical choroid plexus papilloma; medulloblastoma with extensive nodularity; anaplastic medulloblastoma; extraventricular neurocytoma; non-specific variant of dysembryoplastic neuroepithelial tumour (DNT). The new entities and variants are discussed in this review. Moreover, the typing und grading of common-type diffuse gliomas, as well as the WHO grading system, are critically reviewed, particularly with regard to the prognostically important differential diagnosis of diffuse astrocytomas und oligodendrogliomas.

• Authors: S Feiden, W Feiden
• Journal: Der Pathologe (Pathologe) Vol. 29 Issue 6 Pg. 411-21 (Nov 2008) ISSN: 1432-1963 [Electronic] Germany
• Vernacular Title: WHO-Klassifikation der ZNS-Tumoren: Revidierte Fassung von 2007 mit kritischen Anmerkungen zum "Typing" und "Grading" diffuser Gliome.
• PMID: 18820922 (Publication Type: English Abstract, Journal Article)

Topics

• Astrocytoma (classification, pathology)
• Brain Neoplasms (classification, pathology)
• Central Nervous System Neoplasms (classification, pathology)
• Choroid Neoplasms (classification, pathology)
• Glioma (classification, pathology)
• Humans
• Medulloblastoma (classification, pathology)
• Oligodendroglioma (classification, pathology)
• Papilloma (classification, pathology)
• World Health Organization