[Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate].

Abstract

The effects of GABA - docosahexaenoyldopamine (DHED) conjugate on the cerebral haemodynamics and thrombocyte aggregation were evaluated and compared to these of docosahexaenoyldopamine alone. The GABA - DHED conjugate was shown to significantly enhance the cerebral circulation in rats with a model of global transient cerebral ischemia, as compared to the intact animals. Administered alone, DHED increased the blood supply of both intact and ischemic brains to an equal extent. The GABA-DHED conjugate demonstrated the antiaggregative activity, but the effect was less expressed than that of DHED alone.

• Authors: I N Kurdiumov, T S Gan'shina, N R Mirzoian, T M Vasil'eva, V A Makarov, G N Petrukhina, V V Bezuglov, N M Gretskaia, G N Zinchenko, R S Mirzoian
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2008 Jul-Aug Vol. 71 Issue 4 Pg. 26-9 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 18819437 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Platelet Activating Factor
• gamma-Aminobutyric Acid
• Dopamine

Topics

• Animals
• Cerebrovascular Circulation (drug effects)
• Dopamine (analogs & derivatives, pharmacology)
• Humans
• Male
• Platelet Activating Factor (drug effects)
• Rats
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)