Abstract | AIM: METHODS: A mouse model for asthma was used to investigate acetamide-45 on the airway lesions compared with glucocorticoids. The study was conducted on mice sensitized and challenged with ovalbumin and the whole body plethysmography was carried out to assess AHR. The bronchoalveolar lavage (BAL) histopathology was examined. RESULTS: We found that acetamide-45 significantly inhibited the enhanced hyperresponsiveness and eosinophil recruitment in airways with elimination of cAMP-PDE activity in lung tissue. Elevated IL-4 and IL-5 in bronchoalveolar lavage fluid (BALF) in asthmatic mice were markedly decreased. CONCLUSION: Our results indicate that the agent has a potential role in inflammatory disease.
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Authors | Kai Wang, Hua-hao Shen, Hua-qiong Huang, Jun-chun Chen, Zhong Chen |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 29
Issue 10
Pg. 1195-201
(Oct 2008)
ISSN: 1745-7254 [Electronic] United States |
PMID | 18817624
(Publication Type: Journal Article)
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Chemical References |
- Acetamides
- Indoles
- Interleukin-5
- Phosphodiesterase Inhibitors
- acetamide 45
- Interleukin-4
- Interferon-gamma
- Ovalbumin
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Topics |
- Acetamides
(pharmacology)
- Animals
- Bronchial Hyperreactivity
(drug therapy)
- Bronchoalveolar Lavage Fluid
(cytology)
- Eosinophils
(drug effects)
- Hypersensitivity
(pathology)
- Indoles
(pharmacology)
- Inflammation
(metabolism)
- Interferon-gamma
(metabolism)
- Interleukin-4
(metabolism)
- Interleukin-5
(metabolism)
- Leukocytes
(drug effects)
- Lung
(pathology)
- Male
- Mice
- Mice, Inbred BALB C
- Ovalbumin
(immunology)
- Phosphodiesterase Inhibitors
(pharmacology)
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