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Successful treatment of vancomycin-resistant enterococcal ventriculitis in a pediatric patient with linezolid.

Abstract
Although vancomycin-resistant Enterococcus infection of the central nervous system is not common, this organism is becoming an increasing problem in nosocomial infections. We report a 17-month-old male infant with an externalized ventricular peritoneal shunt secondary to infection who subsequently developed a vancomycin-resistant Enterococcus faecium ventriculitis. This infection was successfully treated with a 28-day course of linezolid while monitoring linezolid drug levels in both the cerebral spinal fluid and serum. This case supports the use of linezolid in treating such resistant infections. However, our drug level results suggest that further investigation is needed to determine the optimal dosing of linezolid in treatment of central nervous system infection in pediatric patients.
AuthorsAshley M Maranich, Michael Rajnik
JournalMilitary medicine (Mil Med) Vol. 173 Issue 9 Pg. 927-9 (Sep 2008) ISSN: 0026-4075 [Print] England
PMID18816936 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid
Topics
  • Acetamides (pharmacology, therapeutic use)
  • Aged
  • Anti-Infective Agents (pharmacology, therapeutic use)
  • Bacterial Infections (drug therapy)
  • Brain Diseases (drug therapy, microbiology)
  • Cerebral Ventricles (microbiology)
  • Enterococcus (drug effects)
  • Female
  • Humans
  • Infant
  • Linezolid
  • Male
  • Middle Aged
  • Oxazolidinones (pharmacology, therapeutic use)
  • Vancomycin Resistance

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