Abstract | OBJECTIVES: METHODS: Syrian golden hamsters were injected with N-nitrosobis(2-oxopropyl)amine, once weekly for 6 weeks. Upon the first injection, hamsters were randomized as follows: placebo, low-/high-dose DMAPT (20 and 40 mg/kg per day), low-/high-dose celecoxib (10and 50 mg/kg per day), or combination DMAPT/ celecoxib (low/low, high/high). RESULTS: CONCLUSIONS:
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Authors | Michele T Yip-Schneider, Huangbing Wu, Victor Njoku, Matthew Ralstin, Bryan Holcomb, Peter A Crooks, Sundar Neelakantan, Christopher J Sweeney, C Max Schmidt |
Journal | Pancreas
(Pancreas)
Vol. 37
Issue 3
Pg. e45-53
(Oct 2008)
ISSN: 1536-4828 [Electronic] United States |
PMID | 18815538
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemokines, C
- Cyclooxygenase 2 Inhibitors
- Ki-67 Antigen
- LC-1 compound
- Mucins
- NF-kappa B
- Nitrosamines
- Pyrazoles
- Sesquiterpenes
- Sulfonamides
- Xcl1 protein, mouse
- nitrosobis(2-oxopropyl)amine
- Ptgs2 protein, mouse
- Cyclooxygenase 2
- Celecoxib
- Dinoprostone
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Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(pharmacology)
- Celecoxib
- Cell Proliferation
(drug effects)
- Chemokines, C
(metabolism)
- Cricetinae
- Cyclooxygenase 2
(metabolism)
- Cyclooxygenase 2 Inhibitors
(administration & dosage)
- Dinoprostone
(metabolism)
- Dose-Response Relationship, Drug
- Female
- Ki-67 Antigen
(metabolism)
- Mesocricetus
- Mucins
(metabolism)
- NF-kappa B
(metabolism)
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Nitrosamines
- Pancreatic Neoplasms
(chemically induced, metabolism, pathology, prevention & control)
- Pyrazoles
(administration & dosage)
- Sesquiterpenes
(administration & dosage)
- Sulfonamides
(administration & dosage)
- Time Factors
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