HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cinacalcet suppresses calcification of the aorta and heart in uremic rats.

Abstract
High serum parathyroid hormone levels are associated with vascular calcification. Cinacalcet is a calcimimetic agent that inhibits parathyroid hormone secretion and is used to treat patients with secondary hyperparathyroidism. Here we measured the effects of oral cinacalcet on calcification of the aorta and heart in rats with a remnant kidney (5/6 nephrectomy) model of uremia that were fed a high-phosphate diet containing lactose to accelerate the process of aortic calcification. Alizarin red staining showed that the smooth muscle in the aortic arch of rats with a remnant kidney was calcified. The tissue levels of calcium and phosphorus in the aorta and hearts of these rats were significantly increased compared to sham-operated rats. Expression of the osteoblastic lineage genes osteocalcin, osteopontin and runt-related gene 2 were also increased in the aorta of these rats. Cinacalcet suppressed these calcification-related changes by reducing serum parathyroid hormone, calcium, phosphorus, and the calcium-phosphorus product. Parathyroidectomy also suppressed calcification in this model. We suggest that cinacalcet inhibits calcification of the aorta and heart in uremic patients with secondary hyperparathyroidism by decreasing serum parathyroid hormone levels.
AuthorsTakehisa Kawata, Nobuo Nagano, Masaki Obi, Sonoe Miyata, Chika Koyama, Nami Kobayashi, Sachiko Wakita, Michihito Wada
JournalKidney international (Kidney Int) Vol. 74 Issue 10 Pg. 1270-7 (Nov 2008) ISSN: 1523-1755 [Electronic] United States
PMID18813289 (Publication Type: Journal Article)
Chemical References
  • Naphthalenes
  • Parathyroid Hormone
  • Cinacalcet
Topics
  • Animals
  • Aorta (pathology)
  • Calcinosis (drug therapy, prevention & control)
  • Cinacalcet
  • Disease Models, Animal
  • Hyperparathyroidism, Secondary
  • Myocardium (pathology)
  • Naphthalenes (pharmacology)
  • Parathyroid Hormone (blood)
  • Rats
  • Uremia (complications)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: