Chemical and pharmacological investigations of Metaxya rostrata.

Abstract

In a bioassay-guided approach the chemical composition of rhizomes of Metaxya rostrata (Kunth C. Presl) was studied for the first time. Investigations of the cytotoxicity of extracts and fractions on SW480 colorectal carcinoma cells resulted in the isolation of two polyphenols--cinnamtannin B-1 and aesculitannin B. The structures of the compounds were elucidated by different NMR experiments. Additionally, sugars, common sterols, such as sitosterol, stigmasterol and campesterol, as well as chlorogenic acid and caffeic acid were identified in Metaxya rostrata.

• Authors: Judith Virtbauer, Liselotte Krenn, Hanspeter Kählig, Antje Hüfner, Oliver Donath, Brigitte Marian
• Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 2008 Jul-Aug Vol. 63 Issue 7-8 Pg. 469-75 ISSN: 0939-5075 [Print] Germany
• PMID: 18810987 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Plant Extracts

Topics

• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Ferns (chemistry)
• Humans
• Magnetic Resonance Spectroscopy
• Plant Extracts (chemistry, pharmacology)