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Improved breast cancer survival among hormone replacement therapy users is durable after 5 years of additional follow-up.

AbstractBACKGROUND:
We previously reported that breast cancer patients who used hormone replacement therapy (HRT) had significantly lower stage tumors and higher survival than never-users. We present an update with longer follow-up, HRT use data, and in vitro research.
METHODS:
Our database of 292 postmenopausal breast cancer patients was updated to include HRT type, duration, and disease status. In vitro effects of estrogen (E) and/or medroxyprogesterone (MPA) on breast cancer cell growth were measured.
RESULTS:
Tumor prognostic factors were better and survival rates higher for both E and combination HRT users of any duration. Use greater than 10 years correlated with node-negative disease, mammographically detected tumors, and 100% survival. E supported minimal proliferation; MPA induced cell death; E+MPA results were similar to E alone.
CONCLUSIONS:
HRT users, regardless of type or duration of HRT use, continued to have higher survival rates. In vitro results supported the clinical finding that outcomes for users of E and E+MPA were similar.
AuthorsDara Christante, SuEllen Pommier, Jennifer Garreau, Patrick Muller, Brett LaFleur, Rodney Pommier
JournalAmerican journal of surgery (Am J Surg) Vol. 196 Issue 4 Pg. 505-11 (Oct 2008) ISSN: 1879-1883 [Electronic] United States
PMID18809052 (Publication Type: Journal Article)
Topics
  • Analysis of Variance
  • Breast Neoplasms (drug therapy, pathology)
  • Dose-Response Relationship, Drug
  • Estrogen Replacement Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Neoplasm Staging
  • Postmenopause
  • Prognosis
  • Proportional Hazards Models
  • Statistics, Nonparametric
  • Survival Rate

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