Abstract | BACKGROUND: We previously reported that breast cancer patients who used hormone replacement therapy (HRT) had significantly lower stage tumors and higher survival than never-users. We present an update with longer follow-up, HRT use data, and in vitro research. METHODS: RESULTS:
Tumor prognostic factors were better and survival rates higher for both E and combination HRT users of any duration. Use greater than 10 years correlated with node-negative disease, mammographically detected tumors, and 100% survival. E supported minimal proliferation; MPA induced cell death; E+MPA results were similar to E alone. CONCLUSIONS: HRT users, regardless of type or duration of HRT use, continued to have higher survival rates. In vitro results supported the clinical finding that outcomes for users of E and E+MPA were similar.
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Authors | Dara Christante, SuEllen Pommier, Jennifer Garreau, Patrick Muller, Brett LaFleur, Rodney Pommier |
Journal | American journal of surgery
(Am J Surg)
Vol. 196
Issue 4
Pg. 505-11
(Oct 2008)
ISSN: 1879-1883 [Electronic] United States |
PMID | 18809052
(Publication Type: Journal Article)
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Topics |
- Analysis of Variance
- Breast Neoplasms
(drug therapy, pathology)
- Dose-Response Relationship, Drug
- Estrogen Replacement Therapy
- Female
- Follow-Up Studies
- Humans
- Middle Aged
- Neoplasm Staging
- Postmenopause
- Prognosis
- Proportional Hazards Models
- Statistics, Nonparametric
- Survival Rate
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