DDC-induced retrograde amnesias prevented by injections of dl-DOPS.

Abstract

Injection of a dopamine beta-hydroxylate inhibitor, diethyldithiocarbamate (DDC) in rats 30 min prior to training of a step-down passive avoidance task impaired performance of the task 24 hr later. Similarly, injection of DDC 30 min prior to testing blocked retrieval of a passive avoidance habit trained in normal rats the previous day. Injection of a direct norepinephrine (NE) precursor, dl-thero 3,4-dihydroxyphenylserine (DOPS) 60 min before DDC prevented both amnesias. These data support the hypothesis that reduced levels of NE are responsible for DDC-induced amnesias.

• Authors: M D Hamburg, A Kerr
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 5 Issue 4 Pg. 499-501 (Oct 1976) ISSN: 0091-3057 [Print] United States
• PMID: 188054 (Publication Type: Journal Article)

Chemical References

• Thiocarbamates
• Serine
• Ditiocarb
• Droxidopa

Topics

• Amnesia, Retrograde (chemically induced)
• Animals
• Avoidance Learning (drug effects)
• Ditiocarb (antagonists & inhibitors, pharmacology)
• Droxidopa (pharmacology)
• Humans
• Male
• Memory (drug effects)
• Rats
• Serine (analogs & derivatives)
• Thiocarbamates (antagonists & inhibitors)
• Time Factors