Abstract |
Resistin is an adipokine whose physiologic role in obesity, type II diabetes mellitus, and inflammatory diseases has been a subject of debate because while it is expressed in adipocytes and adipose tissue in mouse, it is expressed in leukocytes, such as macrophages, in human. In the present study, we attempt to define the effect of resistin on human dendritic cells (DCs) derived from CD14(+) monocytes. When DCs were stimulated with lipoteichoic acid (LTA) and treated with various concentrations of resistin, antigen-uptake process and the endocytic capacity of DCs were decreased. It is intriguing that resistin attenuated cytokine production in LTA-primed DCs. Consequently, T cell activity was reduced when lymphocytes were mixed with Staphylococcus aureus-primed autologous DCs treated with resistin compared to S. aureus-primed DCs without resistin. Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs.
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Authors | Young Min Son, Sung Min Ahn, Mi Seon Jang, Yang Soo Moon, Sang Hoon Kim, Kwang-Keun Cho, Seung Hyun Han, Cheol-Heui Yun |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 376
Issue 3
Pg. 599-604
(Nov 21 2008)
ISSN: 1090-2104 [Electronic] United States |
PMID | 18805395
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Immunosuppressive Agents
- Lipopolysaccharides
- Resistin
- Teichoic Acids
- lipoteichoic acid
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Topics |
- Antigen Presentation
(drug effects)
- Cell Differentiation
(drug effects, immunology)
- Cells, Cultured
- Cytokines
(immunology)
- Dendritic Cells
(drug effects, immunology)
- Endocytosis
(drug effects, immunology)
- Humans
- Immunosuppressive Agents
(pharmacology)
- Lipopolysaccharides
(immunology, pharmacology)
- Resistin
(pharmacology)
- Staphylococcus aureus
(immunology)
- Teichoic Acids
(immunology, pharmacology)
- Th1 Cells
(drug effects, immunology)
- Th2 Cells
(drug effects, immunology)
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