Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo).

Abstract	Radiation-induced (RI) peripheral neuropathy is a rare and severe delayed complication of radiotherapy that is spontaneously irreversible, with no standard of treatment. We previously developed a successful antioxidant treatment in RI fibrosis and necrosis. Two patients with progressive worsening RI lumbosacral polyradiculopathy experienced over several years a significant clinical improvement in their neurological sensorimotor symptoms with long-term pentoxifylline-tocopherol-clodronate treatment, and good safety.
Authors	Sylvie Delanian, Jean-Louis Lefaix, Thierry Maisonobe, François Salachas, Pierre-François Pradat
Journal	Journal of the neurological sciences (J Neurol Sci) Vol. 275 Issue 1-2 Pg. 164-6 (Dec 15 2008) ISSN: 0022-510X [Print] Netherlands
PMID	18804790 (Publication Type: Case Reports, Journal Article)
Chemical References	Antioxidants Radiation-Protective Agents Clodronic Acid Tocopherols Pentoxifylline
Topics	Antioxidants (therapeutic use) Clodronic Acid (therapeutic use) Drug Therapy, Combination Humans Male Middle Aged Pentoxifylline (therapeutic use) Polyradiculopathy (drug therapy, etiology) Radiation Injuries (complications) Radiation-Protective Agents (therapeutic use) Tocopherols (therapeutic use)

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