Abstract | PURPOSE: METHODS: A prospective randomized study. SETTING: Medical University Hospital. PATIENTS: 70 infertile PCOS patients; 33 in GnRH antagonist and 37 in GnRH agonist group. RESULTS: Similar mature metaphase II oocyte rate (76% vs. 76%) was observed in both protocols. Optimal pronuclear morphology zygotes dominated in both groups (64% vs. 66%). Transferred embryo quality did not differ in both protocols. No significant differences between both protocols were found in delivery rate (p = 0.481), pregnancy rate (p = 0.810), multiple pregnancy rate (p = 0.501), miscarriage rate (p = 0.154), fertilization rate (p = 0.388) and implantation rate (p = 1.000). Duration of stimulation and total follicle-stimulating hormone (FSH) dose were significantly lower in GnRH antagonist protocol (p = 0.0005). CONCLUSIONS:
GnRH antagonist and agonist protocols in non-obese PCOS patients yield similar embryological and clinical outcomes. Shorter duration of treatment and lower FSH requirement in GnRH antagonist group may be financially beneficial and therefore attractive for patients.
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Authors | Rafal Kurzawa, Przemyslaw Ciepiela, Tomasz Baczkowski, Krzysztof Safranow, Pawel Brelik |
Journal | Journal of assisted reproduction and genetics
(J Assist Reprod Genet)
Vol. 25
Issue 8
Pg. 365-74
(Aug 2008)
ISSN: 1058-0468 [Print] Netherlands |
PMID | 18802744
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gonadotropin-Releasing Hormone
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Topics |
- Abortion, Spontaneous
- Adult
- Female
- Fertilization
- Fertilization in Vitro
(methods)
- Gonadotropin-Releasing Hormone
(agonists, antagonists & inhibitors, therapeutic use)
- Humans
- Male
- Obesity
(complications)
- Oocytes
(cytology)
- Polycystic Ovary Syndrome
(drug therapy)
- Pregnancy
- Pregnancy Rate
- Prospective Studies
- Spermatozoa
(metabolism)
- Treatment Outcome
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