A new clinical bioassay for antipyresis.

Abstract

Three studies that describe antipyretic bioassay are detailed. Reference Standard Endotoxin (RSE) was used to induce fever in healthy male volunteers under randomized, single-dose, double-blind, parallel, and standard drug-control conditions. Thirty minutes before administering RSE, the subjects were medicated with test drug, and oral temperatures were recorded every 15 minutes for 6 to 8 hours. Two NSAIDs and a centrally acting analgesic were evaluated. Both doses of a propionic derivative, three high doses of tebufelone (a new NSAID), as well as the high dose of flupirtine effectively obtunded the fever response to RSE. Adverse reactions consisting of flu-like symptoms such as myalgia, headache, and chills were also significantly reduced with the standard as well as test drugs. The authors conclude that the RSE model is a quick, safe, and reliable method to evaluate antipyresis and to predict other pharmacologic effects of these types of drugs, such as analgesia.

• Authors: F G McMahon, R Vargas
• Journal: Journal of clinical pharmacology (J Clin Pharmacol) Vol. 31 Issue 8 Pg. 736-40 (Aug 1991) ISSN: 0091-2700 [Print] England
• PMID: 1880232 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Alkynes
• Aminopyridines
• Endotoxins
• Phenols
• flupirtine
• tebufelone

Topics

• Adult
• Alkynes (therapeutic use)
• Aminopyridines (therapeutic use)
• Biological Assay (methods)
• Double-Blind Method
• Endotoxins
• Evaluation Studies as Topic
• Fever (drug therapy, etiology)
• Humans
• Male
• Middle Aged
• Phenols (therapeutic use)
• Reference Standards