HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.

Abstract
Inflammatory factors are known to play a key role in promoting tumorigenesis; therefore, it is a promising strategy to inhibit the inflammation for cancer prevention. The current study was performed to investigate the potential effects of chondroitin sulfate (CS) extracted from ascidian tunic on the expression of inflammatory factors induced by treatment with 12- O-tetradecanoylphorbol-13-acetate (TPA) and to elucidate the underlying molecular mechanism of CS action in mouse skin inflammation. TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin. These studies suggest that CS from ascidian tunic may be developed as an effective natural anti-inflammatory agent.
AuthorsCheng-Xiong Xu, Hua Jin, Youn-Sun Chung, Ji-Young Shin, Kee-Ho Lee, George R Beck Jr, Grace N Palmos, Byeong-Dae Choi, Myung-Haing Cho
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 56 Issue 20 Pg. 9667-75 (Oct 22 2008) ISSN: 1520-5118 [Electronic] United States
PMID18800802 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Carcinogens
  • Cell Extracts
  • NF-kappa B
  • Phorbol Esters
  • Vascular Cell Adhesion Molecule-1
  • Chondroitin Sulfates
  • Ptgs2 protein, mouse
  • Cyclooxygenase 2
Topics
  • Animals
  • Carcinogens (pharmacology)
  • Cell Extracts (pharmacology)
  • Chondroitin Sulfates (chemistry, isolation & purification, pharmacology)
  • Cyclooxygenase 2 (genetics, metabolism)
  • Down-Regulation (drug effects)
  • Female
  • Gene Expression (drug effects)
  • Humans
  • Inflammation (drug therapy, genetics, metabolism)
  • Mice
  • Mice, Inbred ICR
  • NF-kappa B (genetics, metabolism)
  • Phorbol Esters (pharmacology)
  • Phosphorylation (drug effects)
  • Random Allocation
  • Signal Transduction
  • Skin (drug effects, metabolism)
  • Urochordata (chemistry, metabolism)
  • Vascular Cell Adhesion Molecule-1 (genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: