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[Oxidative stress level and placental histological changes during preeclampsia].

AbstractBACKGROUND:
Oxidative stress has been related to several conditions during pregnancy (preeclampsia, abortions and premature rupture of membranes); it causes higher sensitivity of the endothelial blood vessel constriction and aggravates the endothelium dependent vasodilatación.
OBJECTIVE:
To determine the oxidative stress level and histological changes in preeclamptic women's placenta.
PATIENTS AND METHOD:
Longitudinal and comparative study. There were included 25 patients referred from second level health units (IMSS, ISSSTE and Hospital General de Zacatecas). To evaluate oxidative stress level, a sample of blood and placenta were obtained during delivery and a second sample was taken during mediate puerperium (10 days).
RESULTS:
In control group, total lipidic peroxide levels in serum were 135.6 +/- 7.3 nmol of MDA/mL of serum, compared with the group of moderate hypertension, which registered 222.0 +/- 35.15 nmol MDA/mL. Total lipidic peroxides in serum during puerperium for control group were 150.4 +/- 30.8 and 183.3 +/- 18.51 nmol MDA/mL for the group of moderate hypertension. Placental lipoperoxidation for control group was 0.40 +/- 0.03 microg MDNg, and of 0.32 +/- 0.03 microg MDN/g for the group of mild hypertension. Patients of moderate hypertension group showed an increase at 34% on placental lipoperoxidation over control group. Placental histological alterations where characterized by vascular remodeling loss, deposits of proteinaceous material and macrophagic process.
CONCLUSION:
Total lipidic peroxide levels in serum increases during preeclampsia. Histological changes refer uterus-placental ischemia that, probably, induces the oxidative stress.
AuthorsJuan Carlos Medrano Rodríguez, Patricia Yahuaca Mendoza, Manuel Presno Bernal, José Luis Alvarado Acosta
JournalGinecologia y obstetricia de Mexico (Ginecol Obstet Mex) Vol. 76 Issue 6 Pg. 319-26 (Jun 2008) ISSN: 0300-9041 [Print] Mexico
Vernacular TitleGrado de estrés oxidativo y cambios histológicos placentarios durante la preeclampsia.
PMID18800588 (Publication Type: Comparative Study, English Abstract, Journal Article)
Topics
  • Adult
  • Female
  • Humans
  • Longitudinal Studies
  • Oxidative Stress
  • Placenta (pathology)
  • Pre-Eclampsia (metabolism, pathology)
  • Pregnancy

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