Abstract | BACKGROUND: Oxidative stress has been related to several conditions during pregnancy ( preeclampsia, abortions and premature rupture of membranes); it causes higher sensitivity of the endothelial blood vessel constriction and aggravates the endothelium dependent vasodilatación. OBJECTIVE: To determine the oxidative stress level and histological changes in preeclamptic women's placenta. PATIENTS AND METHOD: Longitudinal and comparative study. There were included 25 patients referred from second level health units (IMSS, ISSSTE and Hospital General de Zacatecas). To evaluate oxidative stress level, a sample of blood and placenta were obtained during delivery and a second sample was taken during mediate puerperium (10 days). RESULTS: In control group, total lipidic peroxide levels in serum were 135.6 +/- 7.3 nmol of MDA/mL of serum, compared with the group of moderate hypertension, which registered 222.0 +/- 35.15 nmol MDA/mL. Total lipidic peroxides in serum during puerperium for control group were 150.4 +/- 30.8 and 183.3 +/- 18.51 nmol MDA/mL for the group of moderate hypertension. Placental lipoperoxidation for control group was 0.40 +/- 0.03 microg MDNg, and of 0.32 +/- 0.03 microg MDN/g for the group of mild hypertension. Patients of moderate hypertension group showed an increase at 34% on placental lipoperoxidation over control group. Placental histological alterations where characterized by vascular remodeling loss, deposits of proteinaceous material and macrophagic process. CONCLUSION: Total lipidic peroxide levels in serum increases during preeclampsia. Histological changes refer uterus-placental ischemia that, probably, induces the oxidative stress.
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Authors | Juan Carlos Medrano Rodríguez, Patricia Yahuaca Mendoza, Manuel Presno Bernal, José Luis Alvarado Acosta |
Journal | Ginecologia y obstetricia de Mexico
(Ginecol Obstet Mex)
Vol. 76
Issue 6
Pg. 319-26
(Jun 2008)
ISSN: 0300-9041 [Print] Mexico |
Vernacular Title | Grado de estrés oxidativo y cambios histológicos placentarios durante la preeclampsia. |
PMID | 18800588
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Topics |
- Adult
- Female
- Humans
- Longitudinal Studies
- Oxidative Stress
- Placenta
(pathology)
- Pre-Eclampsia
(metabolism, pathology)
- Pregnancy
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