Abstract |
Antiangiogenic drugs are currently tested in haematological malignancies. As these drugs target different angiogenic regulators, and as cancers are inherently heterogeneous, a detailed characterization of angiogenesis in individual cancers is needed. Hence, we measured bone marrow microvessel density (MVD), plasma concentrations of eight angiogenesis-related parameters and the expression in blood mononuclear cells of 40 angiogenesis-related mRNAs in 93 patients with haematological neoplasias (acute myeloid leukaemia; chronic lymphatic leukaemia; multiple myeloma (MM); or non-Hodgkin's lymphoma (NHL)) before start and after completion of cancer therapy. Compared with healthy individuals, the patients had significantly increased bone marrow MVD, especially patients with advanced stage disease. A novel finding was that patients with NHL also had increased bone marrow MVD. The plasma levels of vascular endothelial growth factor ( VEGF), interleukin (IL)-6 and IL-8 were significantly increased. VEGF levels were highest in those who did not achieve complete remission after cancer therapy. The mRNA expression of IL-8 was upregulated 15-fold. Our data show that patients with haematological malignancies have increased bone marrow MVD; hence, supporting the notion that bone marrow angiogenesis plays a role in the pathogenesis and progression of these cancers. VEGF, IL-6 and IL-8 seem to contribute to the malignant phenotype.
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Authors | H F S Negaard, N Iversen, I M Bowitz-Lothe, P M Sandset, B Steinsvik, B Ostenstad, P O Iversen |
Journal | Leukemia
(Leukemia)
Vol. 23
Issue 1
Pg. 162-9
(Jan 2009)
ISSN: 1476-5551 [Electronic] England |
PMID | 18800145
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inducing Agents
- Interleukin-6
- Interleukin-8
- RNA, Messenger
- Vascular Endothelial Growth Factor A
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Angiogenesis Inducing Agents
(blood)
- Bone Marrow
(blood supply)
- Female
- Gene Expression Regulation, Neoplastic
- Hematologic Neoplasms
(pathology)
- Humans
- Interleukin-6
(blood)
- Interleukin-8
(blood)
- Male
- Microvessels
(growth & development)
- Middle Aged
- Neovascularization, Pathologic
- Prospective Studies
- RNA, Messenger
(blood)
- Vascular Endothelial Growth Factor A
(blood)
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