Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects.

Abstract

Using a single-group time-series design, we determined that osmotic diarrhea caused by maltitol ingestion was suppressed by the addition of not only soluble but also insoluble dietary fiber in healthy humans. We then clarified that cellulose delayed gastric emptying in rats. Twenty-seven healthy volunteers ingested maltitol step-wise at doses of 15, 20, 25, 30, 35, 40 and 45 g from small to large amounts. Within that range of ingested amounts, 22 out of 27 subjects experienced osmotic diarrhea from maltitol ingestion, and the minimal dose level of maltitol that induced osmotic diarrhea (MMD) was established for each subject. When 5 g of cellulose was added to the MMD, osmotic diarrhea was suppressed in 13 out of 19 subjects (68.4%), while partially hydrolyzed alginate-Na (PHA-Na), a soluble dietary fiber, suppressed osmotic diarrhea in 10 out of 20 subjects (50.0%). When a mixed solution of cellulose and maltitol was administered to rats, the gastric emptying of maltitol was significantly delayed at 30 and 60 min after administration (p=0.019, p=0.013), respectively. PHA-Na also significantly delayed gastric emptying at 30 min (p=0.013). In conclusion, cellulose can suppress the osmotic diarrhea caused by maltitol ingestion in humans and delay the gastric emptying of maltitol in rats. A new physiological property of cellulose was clarified in this study.

• Authors: Tsuneyuki Oku, Ryoko Hongo, Sadako Nakamura
• Journal: Journal of nutritional science and vitaminology (J Nutr Sci Vitaminol (Tokyo)) Vol. 54 Issue 4 Pg. 309-14 (Aug 2008) ISSN: 0301-4800 [Print] Japan
• PMID: 18797153 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alginates
• Dietary Fiber
• Diuretics, Osmotic
• Sugar Alcohols
• Maltose
• Cellulose
• maltitol

Topics

• Alginates (administration & dosage)
• Animals
• Cellulose (administration & dosage)
• Diarrhea (chemically induced, drug therapy)
• Dietary Fiber (administration & dosage)
• Diuretics, Osmotic (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Interactions
• Female
• Gastric Emptying (drug effects)
• Humans
• Intestine, Small (drug effects, physiology)
• Male
• Maltose (administration & dosage, analogs & derivatives)
• Rats
• Rats, Wistar
• Stomach (drug effects, physiology)
• Sugar Alcohols (administration & dosage)
• Young Adult