| Abstract | We report the first adult case of Influenza A virus infection with acute unilateral oculomotor nerve palsy. Unlike previous reports, our patient showed isolated unilateral oculomotor nerve palsy as soon as she developed general symptoms with Influenza A infection, and demonstrated no significant increases of anti-ganglioside antibodies including anti-GQ1b IgG antibody. She recovered immediately after treatment of oseltamivir phosphate. As for the mechanism by which Influenza A infection caused ophthalmoparesis, small vessel vasculitis due to direct invasion of the virus was speculated. Although influenza encephalitis/encephalopathy including acute necrotizing encephalopathy are most frequently reported in children, it is noteworthy that influenza virus can also cause focal neurological signs such as ophthalmoparesis in adult cases. |
| Authors | Satoshi Yamashita, Yanosuke Kouzaki, Ryoko Kawano, Makoto Tokunaga, Makoto Uchino
(Affiliation: Department of Neurology, Kumamoto Medical Center, National Hospital Organization, Graduate School of Medical Sciences, Kumamoto University, Kumamoto. y-stsh at pg8.so-net.ne.jp)
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| Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 47
Issue 18
Pg. 1627-9
( 2008)
ISSN: 1349-7235 Japan |
| PMID | 18797124
(Publication Type: Case Reports, Journal Article)
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| Chemical References |
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| Topics |
- Adult
- Female
- Humans
- Influenza A Virus, H1N1 Subtype
(isolation & purification)
- Influenza, Human
(complications, drug therapy)
- Ophthalmoplegia
(complications)
- Oseltamivir
(therapeutic use)
|
