Immunoscintigraphy of colorectal carcinoma utilizing 111In-labeled monoclonal antibody conjugate CYT-103.

Abstract

Twelve presurgical patients with colorectal carcinoma received a single intravenous infusion of 0.5-20.0 mg of the radiolabeled monoclonal antibody conjugate CYT-103. This product is an immunoconjugate of B72.3 labeled with Indium-111 (111In). Patients underwent preoperative gamma camera imaging and computed tomographic (CT) scanning of the abdomen and pelvis. Fifteen intraabdominal sites of tumor were found at surgery. Monoclonal antibody imaging detected 87% of these lesions, whereas CT of the abdomen and pelvis detected 47%. Monoclonal antibody imaging identified tumor in 27% of the patients in which CT did not identify any sites of tumor. The results of this study indicate that monoclonal antibody imaging using [111In]CYT-103 is useful for the preoperative evaluation of colorectal carcinoma patients and the results are complimentary to CT of the abdomen and the pelvis.

• Authors: C E Neal, T L Swan, M R Baker, R L Ellis, J G Katterhagen
• Journal: Gastrointestinal radiology (Gastrointest Radiol) Vol. 16 Issue 3 Pg. 251-5 ( 1991) ISSN: 0364-2356 [Print] United States
• PMID: 1879645 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Indium 111In-satumomab pendetide
• Indium Radioisotopes
• Oligopeptides
• Pentetic Acid

Topics

• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal
• Colorectal Neoplasms (diagnostic imaging)
• Female
• Humans
• Indium Radioisotopes
• Male
• Middle Aged
• Oligopeptides
• Pentetic Acid
• Prospective Studies
• Radionuclide Imaging
• Tomography, X-Ray Computed