Comparison of 6-18F-fluorodopamine PET with 123I-metaiodobenzylguanidine and 111in-pentetreotide scintigraphy in localization of nonmetastatic and metastatic pheochromocytoma.

Abstract

UNLABELLED:

We compared functional imaging modalities including PET with 6-(18)F-fluorodopamine ((18)F-DA) with (123)I-metaiodobenzylguanidine ((123)I-MIBG) and somatostatin receptor scintigraphy (SRS) with (111)In-pentetreotide in nonmetastatic and metastatic pheochromocytoma (PHEO).

METHODS:

We studied 25 men and 28 women (mean age +/- SD, 44.2 +/- 14.2 y) with biochemically proven nonmetastatic (n = 17) or metastatic (n = 36) PHEO. Evaluation included anatomic imaging with CT or MRI and functional imaging that included at least 2 nuclear medicine modalities: (18)F-DA PET, (123)I-MIBG scintigraphy, or SRS. Sensitivity of functional imaging versus anatomic imaging was assessed on a per-patient and a per-region basis.

RESULTS:

For this available cohort, on a per-patient basis overall sensitivity (combined for nonmetastatic and metastatic PHEO) was 90.2% for (18)F-DA PET, 76.0% for (123)I-MIBG scintigraphy, and 22.0% for SRS. On a per-region basis, overall sensitivity was 75.4% for (18)F-DA PET, 63.4% for (123)I-MIBG scintigraphy, and 64.0% for SRS.

CONCLUSION:

If available, (18)F-DA PET should be used in the evaluation of PHEO, because it is more sensitive than (123)I-MIBG scintigraphy or SRS. If (18)F-DA PET is not available, (123)I-MIBG scintigraphy (for nonmetastatic or adrenal PHEO) and SRS (for metastatic PHEO) should be the first alternative imaging methods to be used.

• Authors: Ioannis Ilias, Clara C Chen, Jorge A Carrasquillo, Millie Whatley, Alexander Ling, Ivica Lazúrová, Karen T Adams, Shiromi Perera, Karel Pacak
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 49 Issue 10 Pg. 1613-9 (Oct 2008) ISSN: 0161-5505 [Print] United States
• PMID: 18794260 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Fluorine Radioisotopes
• Indium Radioisotopes
• Iodine Radioisotopes
• Radiopharmaceuticals
• 3-Iodobenzylguanidine
• 6-fluorodopamine
• Dopamine

Topics

• 3-Iodobenzylguanidine
• Diagnostic Imaging (methods)
• Dopamine (analogs & derivatives)
• Female
• Fluorine Radioisotopes
• Humans
• Indium Radioisotopes (pharmacology)
• Iodine Radioisotopes
• Male
• Neoplasm Metastasis
• Pheochromocytoma (diagnostic imaging)
• Positron-Emission Tomography (methods)
• Radionuclide Imaging (methods)
• Radiopharmaceuticals
• Retrospective Studies