| Abstract | Methotrexate (MTX) has been increasingly administered to patients with rheumatoid arthritis (RA), resulting in methotrexate-associated lymphoproliferative disorder (MTX-LPD) in patients. We reported three case of rheumatoid arthritis (RA) undergoing methotrexate (MTX) therapy who developed MTX-LPD. A 72-year-old woman treated with MTX since December 1997 (total dose 3684 mg) presented with swelling of the right tonsil in October 2006, and diffuse large B-cell lymphoma was diagnosed by tonsil biopsy and positive EBER1. When MTX therapy was interrupted, the tonsil was shrank and chemotherapy was not necessary. She followed a good clinical course for 12 months. Two other patients treated with MTX for RA for several years presented with enlarged neck lymph nodes and were diagnosed with MTX-LPD. Neck lymph nodes shrank upon MTX withdrawal in several weeks. There have been no signs of recurrence in these cases and they followed a good clinical course. The oncogenic potential of MTX and RA is reviewed. |
| Authors | Yoshiya Ishida, Atsuyoshi Asahi, Tetsuji Wada, Naoki Kanai, Yuuki Kobayashi, Shigetaka Moriai, Kan Kishibe, Yasuaki Harabuchi
(Affiliation: Department of Otolaryngology-Head and Neck Surgery, Kitami Red Cross Hospital, Kitami.)
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| Journal | Nippon Jibiinkoka Gakkai kaiho
(Nippon Jibiinkoka Gakkai Kaiho)
Vol. 111
Issue 8
Pg. 594-8
(Aug 2008)
ISSN: 0030-6622 Japan |
| PMID | 18788425
(Publication Type: Case Reports, English Abstract, Journal Article)
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| Chemical References |
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| Topics |
- Aged
- Arthritis, Rheumatoid
(drug therapy)
- Female
- Humans
- Lymphoproliferative Disorders
(chemically induced)
- Methotrexate
(adverse effects)
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