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Germline MC1R variants and BRAF mutant melanoma.

Abstract
Recent studies have demonstrated that melanocortin-1 receptor (MC1R) variants increase the risk of melanomas harboring BRAF mutations. This finding provides insight into the relationship between host genotype and selection for somatic mutation type. Additional larger studies are required in diverse populations to further examine the interaction between MC1R and BRAF in different melanoma subtypes.
AuthorsElke Hacker, Nicholas K Hayward
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 128 Issue 10 Pg. 2354-6 (Oct 2008) ISSN: 1523-1747 [Electronic] United States
PMID18787543 (Publication Type: Comment, Editorial)
Chemical References
  • Receptor, Melanocortin, Type 1
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
Topics
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Germ-Line Mutation
  • Humans
  • Melanoma (genetics)
  • Mutation
  • Proto-Oncogene Proteins B-raf (genetics)
  • Receptor, Melanocortin, Type 1 (genetics)
  • Skin Neoplasms (genetics)

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