Abstract | OBJECTIVES: METHODS: RESULTS: We found that, in contrast to obese rats, garlic decreased IL-10/ TNF-alpha ratio, despite decreasing TNF-alpha in alloxan diabetic rats in agreement with the histology, which revealed more prominent improvement in the obese group. Moreover, the effect of garlic was not linked to improvement of IR in obese rats. CONCLUSION: We conclude that IL-10/ TNF-alpha ratio may be considered as a convenient biomarker for investigation of fatty liver of different grades, apart from being associated with IR, and immunomodulation of this ratio in favor of increasing it may exert significant improvement.
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Authors | Reem M Hashem, Mona F Mahmoud, Mohamed A El-Moselhy, Hala M Soliman |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 20
Issue 10
Pg. 995-1001
(Oct 2008)
ISSN: 1473-5687 [Electronic] England |
PMID | 18787467
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Tumor Necrosis Factor-alpha
- Interleukin-10
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Topics |
- Animals
- Biomarkers
(blood)
- Diabetes Mellitus, Experimental
(metabolism)
- Fatty Liver
(blood, pathology)
- Garlic
- Insulin Resistance
- Interleukin-10
(blood)
- Liver
(pathology)
- Male
- Obesity
(metabolism, pathology)
- Prognosis
- Rats
- Rats, Wistar
- Tumor Necrosis Factor-alpha
(blood)
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