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[Effects of Jinlong Capsule on expressions of interleukin-2 and soluble interleukin-2 receptor in patients with primary liver cancer after transarterial chemoembolization therapy].

AbstractOBJECTIVE:
To observe and discuss the dynamic changes of interleukin-2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) and their significance in the patients with primary liver cancer after transarterial chemoembolization (TACE) therapy combined with Jinglong Capsule.
METHODS:
A total of 48 patients with primary liver cancer, who failed to be treated by major surgery, were randomly divided into two groups: Jinlong Capsule group (TACE therapy plus Jinlong Capsule) and control group (TACE therapy alone). There were 24 cases in each group. The levels of peripheral blood IL-2 and slL-2R were measured before the first TACE and 1, 7 and 15 days after the second TACE respectively by using double-antibody sandwich enzyme-linked immunosorbent assay. The data from Jinlong Capsule group were compared with those from the control group.
RESULTS:
The level of sIL-2R in Jinlong Capsule group was significantly lower than that in the control group (P<0.05), while the level of IL-2 was significantly higher than that in the control group (P<0.05).
CONCLUSION:
Jinlong Capsule can significantly improve the lymphocyte function of the patients with primary liver cancer after TACE. The levels of IL-2 and sIL-2R can be considered as the valuable parameters for evaluating the effects on primary liver cancer, and Jinlong Capsule is helpful for the patients with primary liver cancer.
AuthorsHuo-Jun Zhang, Ji-Jin Yang, Wei-Xing Wang, Xu Jiang, Yan-Jun Mao, Chao-Ai Yang, Ji-Xiang Guo
JournalZhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 6 Issue 9 Pg. 907-10 (Sep 2008) ISSN: 1672-1977 [Print] China
PMID18782532 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Adjuvants, Immunologic
  • Capsules
  • Drugs, Chinese Herbal
  • IL2 protein, human
  • Interleukin-2
  • Receptors, Interleukin-2
Topics
  • Adjuvants, Immunologic (therapeutic use)
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
  • Capsules
  • Carcinoma, Hepatocellular (blood, drug therapy)
  • Chemoembolization, Therapeutic (methods)
  • Drug Therapy, Combination
  • Drugs, Chinese Herbal (therapeutic use)
  • Female
  • Humans
  • Interleukin-2 (blood)
  • Liver Neoplasms (blood, drug therapy)
  • Male
  • Middle Aged
  • Phytotherapy
  • Receptors, Interleukin-2 (blood)

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