A phase 2 trial of whole-brain radiotherapy combined with intravenous chemotherapy in patients with brain metastases from breast cancer.

Abstract

BACKGROUND:

A study was conducted to determine the efficacy, tolerability, and safety of concurrent cisplatin and vinorelbine chemotherapy and radiotherapy in patients with previously untreated brain metastases from breast cancer.

METHODS:

Twenty-five patients with untreated brain metastases from breast cancer were treated with cisplatin (at a dose of 20 mg/m(2)/day, Days 1-5) and vinorelbine (6-mg/m(2) bolus on Day 1 and 6 mg/m(2)/day continuous infusion on Days 1-5) chemotherapy combined with concurrent 30-gray fractionated external-beam radiotherapy. Chemotherapy was given at 3-week intervals for a total of 4 cycles. Primary endpoint was the rate of radiologic response of brain metastases.

RESULTS:

Complete response in the brain was observed in 3 patients, and partial response was noted in 16 patients, yielding a 76% response rate in the brain. The overall systemic response rate was 44%. Progression-free and overall survival were 3.7 months and 6.5 months, respectively. Overall toxicity was acceptable; nonhematologic grade 3-4 events were noted in 5 (20%) patients, and there were no toxic deaths.

CONCLUSIONS:

Concurrent chemoradiation with cisplatin and vinorelbine for brain metastases from breast cancer appears to be active and well tolerated.

• Authors: Philippe A Cassier, Isabelle Ray-Coquard, Marie-Pierre Sunyach, Laurence Lancry, Jean-Paul Guastalla, Céline Ferlay, Frédéric Gomez, Hervé Curé, Alain Lortholary, Line Claude, Jean-Yves Blay, Thomas Bachelot
• Journal: Cancer (Cancer) Vol. 113 Issue 9 Pg. 2532-8 (Nov 01 2008) ISSN: 0008-543X [Print] United States
• PMID: 18780315 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Vinblastine
• Cisplatin
• Vinorelbine

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Brain Neoplasms (drug therapy, radiotherapy, secondary, therapy)
• Breast Neoplasms (drug therapy, pathology, radiotherapy, therapy)
• Carcinoma, Ductal, Breast (drug therapy, radiotherapy, secondary, therapy)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cranial Irradiation
• Female
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Neoadjuvant Therapy
• Prognosis
• Remission Induction
• Survival Rate
• Vinblastine (administration & dosage, analogs & derivatives)
• Vinorelbine