HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Development of slow releasing anticancer drug based with absorbable biomaterial chitin].

Abstract
To have a comparatively more slowly releasing anticancer drug with effectiveness, Plachitin was prepared by chemical combination of CDDP and chitin (poly-N-acetyl-D-glucosamine). Chitin is absorbed by the living body over several months. To investigate the slow releasing property, it was implanted in thigh muscle of mice and rabbit. Pt level in different organs and in urine was measured at regular intervals. Pt level in implanted muscles was higher in comparison to low serum level in mice. It was released slowly over 1 to 2 months in mice, whereas in rabbit it took about three weeks. Pt releasing period of the Plachitin was different according to the adopted method of implantation. Anticancer effect of Plachitin was investigated by injecting 180 sarcoma cells in mouse peritoneal cavity and subsequent implantation of Plachitin. In control groups chitin was used instead of Plachitin. The survival rate of mice in the Plachitin group after 14 days was higher than in the chitin group, and the anticancer effect of the Plachitin was confirmed.
AuthorsK Suzuki, T Nakamura, M Tachibana, T Koto, H Yoshimura, S Abe, K Kifune, R Tsurutani, M Yoshimura, Y Nakamura
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 18 Issue 11 Pg. 1833-6 (Aug 1991) ISSN: 0385-0684 [Print] Japan
PMID1877826 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Chitin
  • Platinum
  • Cisplatin
  • Acetylglucosamine
Topics
  • Absorption
  • Acetylglucosamine (administration & dosage, pharmacokinetics)
  • Animals
  • Chitin
  • Cisplatin (administration & dosage, pharmacokinetics)
  • Delayed-Action Preparations
  • Mice
  • Platinum (blood)
  • Rabbits
  • Sarcoma 180 (drug therapy, metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: