Carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus: effects of a low-fat, high-carbohydrate diet vs a diet high in monounsaturated fatty acids.

Abstract

Nineteen patients affected by non-insulin dependent diabetes mellitus (NIDDM), in good glycemic control (fasting plasma glucose 7.2 +/- 0.3 mmol/L, glycosylated hemoglobin 6.3 +/- 0.2%), underwent three isocaloric dietary phases. In phases 1 and 3 the diet was rich in complex carbohydrates (Carbo) whereas in phase 2 it was rich in monounsaturated fatty acids (Mono). Plasma glucose concentrations were 7.1 +/- 0.3 and 7.2 +/- 0.3 mmol/L for the two Carbo phases and 7.5 +/- 0.4 mmol/L for the Mono phase (NS). Plasma total cholesterol values for the Carbo phases were 6.2 +/- 0.2 and 6.4 +/- 0.2 mmol/L, respectively, and 6.5 +/- 0.2 mmol/L on the Mono phase (NS). Similarly, no significant changes were noticed for plasma triglycerides and high-density-lipoprotein (HDL) cholesterol. Thus, both diets were well-tolerated and did not alter glucose homeostasis or worsen plasma lipid concentrations. Consequently, these results suggest that a wider dietary choice can be made available to NIDDM patients without producing unwanted side effects.

• Authors: A Bonanome, A Visonà, L Lusiani, G Beltramello, L Confortin, S Biffanti, F Sorgato, F Costa, A Pagnan
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 54 Issue 3 Pg. 586-90 (Sep 1991) ISSN: 0002-9165 [Print] United States
• PMID: 1877514 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Carbohydrates
• Dietary Fats
• Fatty Acids, Monounsaturated
• Lipids

Topics

• Adult
• Carbohydrate Metabolism
• Diabetes Mellitus, Type 2 (diet therapy, metabolism)
• Dietary Carbohydrates (pharmacology)
• Dietary Fats (administration & dosage, pharmacology)
• Fatty Acids, Monounsaturated (administration & dosage, pharmacology)
• Female
• Humans
• Lipid Metabolism
• Lipids (blood)
• Male
• Middle Aged