Abstract | OBJECTIVES: METHODS: RESULTS: Total MFIS scores decreased by 7.6 +/- 16.4 from 34.6 to 27.0 (p < or = 0.001). Significant reductions were observed on all three subscales of the MFIS. Fatigue symptoms, assessed using a visual analogue scale, decreased by 1.04 +/- 2.88 cm from 4.47 cm to 3.43 cm (p < or = 0.001). The proportion of patients absent from work at least once was reduced by a factor of two from 65.1% to 30.1% (p < or = 0.001). Tolerance to treatment was rated as very good or good in 78.3% of patients. Adverse effects, most frequently local injection site reactions, were reported in 15.1% of patients. CONCLUSION: Treatment with glatiramer acetate was associated with a significant improvement in fatigue symptoms and a marked reduction in absence from work. Treatment was well-tolerated. Such benefits are of relevance to overall patient well-being.
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Authors | Tjalf Ziemssen, Josef Hoffman, Rainer Apfel, Simone Kern |
Journal | Health and quality of life outcomes
(Health Qual Life Outcomes)
Vol. 6
Pg. 67
(Sep 05 2008)
ISSN: 1477-7525 [Electronic] England |
PMID | 18775064
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunosuppressive Agents
- Peptides
- Glatiramer Acetate
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Topics |
- Absenteeism
- Adult
- Disability Evaluation
- Fatigue
(classification, drug therapy, etiology)
- Female
- Germany
- Glatiramer Acetate
- Humans
- Immunosuppressive Agents
(adverse effects, therapeutic use)
- Male
- Multiple Sclerosis, Relapsing-Remitting
(complications, drug therapy)
- Observation
- Peptides
(adverse effects, therapeutic use)
- Prospective Studies
- Sickness Impact Profile
- Surveys and Questionnaires
- Treatment Outcome
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