Effect of bradyarrhythmia on the plasma levels of N-terminal pro-brain natriuretic peptide.

Abstract

To investigate the effect of bradyarrhythmia on the plasma levels of NT-proBNP, patients without defined ventricular diseases were enrolled in this study: group A, 42 patients without arrhythmia; group B, 43 patients with sick sinus syndrome; group C, 22 patients with II degrees atrioventricular block (AVB); group D, 35 patients with III degrees AVB and group E, 35 patients with persistent atrial fibrillation. The plasma levels of NT-proBNP were determined and analyzed. The NT-proBNP levels were lower in group A and B than in group C, D and E (P<0.01), and in group C than in group D and E (P<0.001). Multivariate analysis revealed age and the severity of atrioventricular asynchrony were independent determinants of NT-proBNP levels (P<0.001). These results implicated that the plasma levels of NT-proBNP in patients with bradyarrhythmia increased in proportion to aggravation of atrioventricular asynchrony.

• Authors: Wenzhi Pan, Yangang Su, Kai Hu, Xianhong Shu, Junbo Ge
• Journal: International journal of cardiology (Int J Cardiol) Vol. 136 Issue 1 Pg. 105-7 (Jul 24 2009) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 18774614 (Publication Type: Comparative Study, Letter)

Chemical References

• Biomarkers
• Peptide Fragments
• Protein Precursors
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Bradycardia (blood, diagnosis, physiopathology)
• Cardiac Pacing, Artificial
• Female
• Humans
• Male
• Middle Aged
• Natriuretic Peptide, Brain (blood)
• Peptide Fragments (blood)
• Protein Precursors (blood)