The small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation.

Abstract

This is the first study to demonstrate that the small-molecule Bcl-2 inhibitor HA14-1 renders human cervical cancer cells and their Bcl-2 overexpressing radioresistant counterparts, but not normal fibroblasts, more susceptible to heavy ions. Thus, Bcl-2 may be an attractive target for improving the efficacy of heavy-ion therapy.

• Authors: Nobuyuki Hamada, Keiko Kataoka, Sakura Sora, Takamitsu Hara, Motoko Omura-Minamisawa, Tomoo Funayama, Tetsuya Sakashita, Takashi Nakano, Yasuhiko Kobayashi
• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 89 Issue 2 Pg. 227-30 (Nov 2008) ISSN: 0167-8140 [Print] Ireland
• PMID: 18774194 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzopyrans
• Nitriles
• Photosensitizing Agents
• Proto-Oncogene Proteins c-bcl-2
• ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Topics

• Benzopyrans (pharmacology)
• Cell Death (radiation effects)
• Cell Survival (radiation effects)
• Female
• Fibroblasts (radiation effects)
• Heavy Ions
• Humans
• Nitriles (pharmacology)
• Photosensitizing Agents (pharmacology)
• Proto-Oncogene Proteins c-bcl-2 (antagonists & inhibitors)
• Radiation Tolerance
• Radiation, Ionizing
• Tumor Cells, Cultured
• Uterine Cervical Neoplasms (pathology, radiotherapy)