Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: a case report.

Abstract

A 42-year-old man presented with severe abdominal pain, constipation, and hematuria. The patient had a history of seminoma treated by chemotherapy followed by bilateral orchiectomy and retroperitoneal lymph node dissection 16 years earlier. A computed tomography (CT) scan showed a 8.0 x 6.0 x 5.0 cm mass in the retrovesical space, encompassing the left side of his proximal bladder, the prostate, and the rectum. A urine cytologic specimen showed loosely cohesive cell clusters composed of highly atypical large cells and occasional large, single cells with macronucleoli present in a background of mainly lymphocytes and histiocytes was diagnosed as recurrent seminoma. Prostate biopsies showed extensively necrotic seminoma with accompanying granulomatous reaction. The tumor cells were immunoreactive for c-kit (CD117), placental-like alkaline phosphatase (PLAP), D2-40, and OCT4. To our knowledge, this is the second report on urine cytology of metastatic seminoma.

• Authors: Mariam Alsharif, Deniz L Aslan, Jose Jessurun, H Evin Gulbahce, Stefan E Pambuccian
• Journal: Diagnostic cytopathology (Diagn Cytopathol) Vol. 36 Issue 10 Pg. 734-8 (Oct 2008) ISSN: 1097-0339 [Electronic] United States
• PMID: 18773441 (Publication Type: Case Reports, Journal Article)

Chemical References

• Isoenzymes
• Octamer Transcription Factor-3
• POU5F1 protein, human
• germ-cell AP isoenzyme
• Proto-Oncogene Proteins c-kit
• Alkaline Phosphatase

Topics

• Adult
• Alkaline Phosphatase (metabolism)
• Biopsy
• Humans
• Isoenzymes (metabolism)
• Male
• Octamer Transcription Factor-3 (metabolism)
• Prostate (metabolism, pathology)
• Prostatic Neoplasms (diagnosis, secondary, urine)
• Proto-Oncogene Proteins c-kit (metabolism)
• Seminoma (diagnosis, secondary, urine)
• Testicular Neoplasms (pathology)
• Urinary Bladder Neoplasms (diagnosis, secondary, urine)
• Urine (cytology)