| Abstract | Long-term efficacy of acetyl-cholinesterase-inhibitor (ACHEI) treatment in mild-to-moderate Alzheimer's disease (AD) is of great relevance for clinical routine and has been investigated over a 21-month period of treatment in a "real word" population. We investigated cognitive (mini mental state examination=MMSE) and functional (instrumental activities of daily living=IADL; activities of daily living=ADL) outcomes in 427 AD patients throughout the above period. At the end of the study, first-time drug takers (naives) declined by 1.2 MMSE points, whereas non-naives by 3.8 points. Predictors of responsiveness for first-time drug takers were MMSE score at baseline and MMSE points gained at 3 months of treatment. Further investigations are needed to shed light on the characteristics of responsiveness to a tailored ACHEI treatment for dementia. |
| Authors | Marco Calabria, Cristina Geroldi, Giulia Lussignoli, Federica Sabbatini, Orazio Zanetti
(Affiliation: U.O. Alzheimer, IRCCS San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, I-25123 Brescia, Italy.)
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| Journal | Archives of gerontology and geriatrics
(Arch Gerontol Geriatr)
2009 Jul-Aug
Vol. 49
Issue 1
Pg. e6-11
ISSN: 1872-6976 [Electronic] Netherlands |
| PMID | 18768226
(Publication Type: Journal Article)
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| Chemical References |
- Cholinesterase Inhibitors
|
| Topics |
- Aged
- Alzheimer Disease
(drug therapy)
- Cholinesterase Inhibitors
(therapeutic use)
- Cognition Disorders
(diagnosis, drug therapy)
- Female
- Humans
- Male
- Neuropsychological Tests
- Severity of Illness Index
- Treatment Outcome
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