Effect of selenium compound (selol) on the opioid activity in vincristine induced hyperalgesia.

Abstract

PURPOSE:

Effect of organoselenium compound (selol), on antinociceptive action of opioid agonists in vincristine neuropathic pain model was investigated.

METHODS:

The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto.

RESULTS:

Daily administration of VIN (70 microg/kg, iv) resulted in progressive decrease of pain threshold. Neither morphine, fentanyl nor buprenorphine administered alone in 5 consecutive days modified the vincristine-induced hyperalgesia, whereas selol slightly increased the nociceptive threshold. Co-administration of selol with opioids markedly enhanced the analgesic activity of all three investigated compounds.

CONCLUSIONS:

Therefore, concomitant administration of selenium and opioids may be beneficial in terminal neoplastic states.

• Authors: Magdalena Bujalska, Stanisław Witold Gumułka
• Journal: Neuro endocrinology letters (Neuro Endocrinol Lett) Vol. 29 Issue 4 Pg. 552-7 (Aug 2008) ISSN: 0172-780X [Print] Sweden
• PMID: 18766156 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics, Opioid
• Selenium Compounds
• selol
• Vincristine

Topics

• Analgesics, Opioid (agonists, metabolism, therapeutic use)
• Animals
• Hyperalgesia (chemically induced, drug therapy)
• Male
• Pain (chemically induced, drug therapy)
• Pain Threshold (drug effects)
• Rats
• Rats, Wistar
• Selenium Compounds (metabolism)
• Vincristine (adverse effects, pharmacology)