Emerging antiviral drugs.

Abstract

Foremost among the newly described antiviral agents that may be developed into drugs are, for the treatment of human papilloma virus (HPV) infections, cPrPMEDAP; for the treatment of herpes simplex virus (HSV) infections, BAY 57-1293; for the treatment of varicella-zoster virus (VZV) infections, FV-100 (prodrug of Cf 1743); for the treatment of cytomegalovirus (CMV) infections, maribavir; for the treatment of poxvirus infections, ST-246; for the treatment of hepatitis B virus (HBV) infections, tenofovir disoproxil fumarate (TDF) (which in the meantime has already been approved in the EU); for the treatment of various DNA virus infections, the hexadecyloxypropyl (HDP) and octadecyloxyethyl (ODE) prodrugs of cidofovir; for the treatment of orthomyxovirus infections (i.e., influenza), peramivir; for the treatment of hepacivirus infections (i.e., hepatitis C), the protease inhibitors telaprevir and boceprevir, the nucleoside RNA replicase inhibitors (NRRIs) PSI-6130 and R1479, and various non-nucleoside RNA replicase inhibitors (NNRRIs); for the treatment of human immunodeficiency virus (HIV) infections, integrase inhibitors (INIs) such as elvitegravir, nucleoside reverse transcriptase inhibitors (NRTIs) such as apricitabine, non-nucleoside reverse transcriptase inhibitors (NNRTIs) such as rilpivirine and dapivirine; and for the treatment of both HCV and HIV infections, cyclosporin A derivatives such as the non-immunosuppressive Debio-025.

• Authors: Erik De Clercq
• Journal: Expert opinion on emerging drugs (Expert Opin Emerg Drugs) Vol. 13 Issue 3 Pg. 393-416 (Sep 2008) ISSN: 1744-7623 [Electronic] England
• PMID: 18764719 (Publication Type: Journal Article, Review)

Chemical References

• Anti-HIV Agents
• Antiviral Agents
• HIV Protease Inhibitors
• Integrase Inhibitors
• Protease Inhibitors
• Reverse Transcriptase Inhibitors

Topics

• Anti-HIV Agents (therapeutic use)
• Antiviral Agents (therapeutic use)
• DNA Virus Infections (drug therapy)
• HIV Protease Inhibitors (therapeutic use)
• Hepatitis, Viral, Human (drug therapy)
• Humans
• Integrase Inhibitors (therapeutic use)
• Protease Inhibitors (therapeutic use)
• RNA Virus Infections (drug therapy)
• Reverse Transcriptase Inhibitors (therapeutic use)
• Virus Diseases (drug therapy)