| Abstract | Geschwind and Behan (1982) and Geschwind and Galaburda (1985a, 1985b, 1985c) suggested a correlation between brain laterality and immune disorders. To test whether this hypothesis holds true not only for the frequency of immune diseases and circulating autoantibodies, but extends also to cellular immunity, we examined the association between handedness and markers of cellular immunity. Twenty-seven left-handed and 37 right-handed subjects were serologically screened for cellular parameters and 22 left-handed subjects were typed for human leukocyte antigen (HLA). When compared to the right-handers, the left-handed group showed a significant decrease in the inflammatory cell types CD3(+) T cells (total T cells), CD4(+) T cells (T-helper cells), and HLA-Dr (MHC-II, antigen-presenting cells) as well as in the CD19(+) cells (B cells) and CD16/CD57(+) cells (natural killer cells). We assume a relationship exists between cerebral hemispheric specialisation and the immune system not only for humoral but also for cellular immunity, and we discuss the role of the major histocompatibility complex in neurological and immunological development. |
| Authors | Charis Lengen, Marianne Regard, Helen Joller, Theodor Landis, Patrice Lalive
(Affiliation: Clinic Schloessliöä AG, Private Psychiatric Hospital, Schloesslistrasse 8, CH-8618 Oetwil am See, Switzerland. charis.lengen at schloessli.ch)
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| Journal | Brain and cognition
(Brain Cogn)
Vol. 69
Issue 1
Pg. 188-93
(Feb 2009)
ISSN: 1090-2147 United States |
| PMID | 18762362
(Publication Type: Journal Article)
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