Albaconol, a plant-derived small molecule, inhibits macrophage function by suppressing NF-kappaB activation and enhancing SOCS1 expression.

Abstract

Discovery and functional identification of plant-derived small compounds as the immunosuppressant attract much attention these years. Albaconol is a new kind of small compound, prenylated resorcinol, isolated from the fruiting bodies of the inedible mushroom Albatrellus confluens. Our previous studies showed that albaconol can inhibit tumor cell growth and dendritic cell maturation. However, the immunomodulatory roles and the underlying mechanisms of albaconol have not been fully understood. In this study we investigated the effects of albaconol on the proliferation and LPS-induced proinflammatory cytokine production of macrophages. Albaconol, when used at a dose higher than 1.0 microg/ml, inhibited proliferation of RAW264.7 cells in a dose- and time-dependent manner, and could induce cellular apoptosis when used at high dosage (>or= 7.5 microg/ml). Furthermore, we found that albaconol used at a lower dosage without apoptosis induction could significantly inhibit LPS-induced TNF-alpha, IL-6, IL-1beta and NO production in RAW264.7 cells. The inhibition of NF-kappaB activation and enhancement of SOCS1 expression in LPS-stimulated macrophages by albaconol may contribute to the above immunosuppressive or anti-inflammatory activities of albaconol. Our results suggest that albaconol may be a potential immunosuppressive and anti-inflammatory drug.

• Authors: Qiuyan Liu, Xiaoli Shu, Li Wang, Anna Sun, Jikai Liu, Xuetao Cao
• Journal: Cellular & molecular immunology (Cell Mol Immunol) Vol. 5 Issue 4 Pg. 271-8 (Aug 2008) ISSN: 1672-7681 [Print] China
• PMID: 18761814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Bridged Bicyclo Compounds
• Cytokines
• Immunosuppressive Agents
• Lipopolysaccharides
• NF-kappa B
• Phenols
• Socs1 protein, mouse
• Suppressor of Cytokine Signaling 1 Protein
• Suppressor of Cytokine Signaling Proteins
• albaconol
• Nitric Oxide

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Apoptosis (drug effects)
• Bridged Bicyclo Compounds (pharmacology)
• Cell Line
• Cell Proliferation (drug effects)
• Cytokines (biosynthesis, metabolism)
• Dose-Response Relationship, Drug
• Immunosuppressive Agents (pharmacology)
• Lipopolysaccharides (immunology)
• Macrophage Activation
• Macrophages (cytology, drug effects, immunology, metabolism)
• Mice
• NF-kappa B (antagonists & inhibitors, immunology, metabolism)
• Nitric Oxide (biosynthesis)
• Phenols (pharmacology)
• Suppressor of Cytokine Signaling 1 Protein
• Suppressor of Cytokine Signaling Proteins (biosynthesis)