Abstract | PURPOSE: METHODS AND MATERIALS: Male mice harboring androgen-dependent LAPC-4 xenograft tumors were treated with selenite (2 mg/kg intraperitoneally three times per week) or vehicle for 42 days. In addition, androgen-independent LAPC-4 xenograft tumors were generated in female mice over 4 to 6 months. Once established, androgen-independent LAPC-4 tumor fragments were passaged into female mice and were treated with selenite or vehicle for 42 days. Changes in tumor volume and serum PSA levels were assessed. RESULTS:
Selenite significantly decreased androgen-dependent LAPC-4 tumor growth in male mice over 42 days (p < 0.001). Relative tumor volume was decreased by 41% in selenite-treated animals compared with vehicle-treated animals. The inhibition of LAPC-4 tumor growth corresponded to a marked decrease in serum PSA levels (p < 0.01). In the androgen-independent LAPC-4 tumors in female mice, selenite treatment decreased tumor volume by 58% after 42 days of treatment (p < 0.001). CONCLUSIONS:
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Authors | Rumi S Bhattacharyya, Bryan Husbeck, David Feldman, Susan J Knox |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 72
Issue 3
Pg. 935-40
(Nov 01 2008)
ISSN: 1879-355X [Electronic] United States |
PMID | 18760546
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Androgens
- Antineoplastic Agents
- Biomarkers
- RNA, Messenger
- RNA, Neoplasm
- Prostate-Specific Antigen
- Sodium Selenite
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Topics |
- Androgens
(physiology)
- Animals
- Antineoplastic Agents
(pharmacology)
- Biomarkers
(blood)
- Cell Division
(drug effects)
- Cell Line, Tumor
- Female
- Humans
- Male
- Mice
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(genetics, pathology)
- RNA, Messenger
(genetics)
- RNA, Neoplasm
(genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Sodium Selenite
(pharmacology)
- Transplantation, Heterologous
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