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[Antiviral activity of arbidol and its derivatives against the pathogen of severe acute respiratory syndrome in the cell cultures].

Abstract
Experimental studies of arbidol and arbidol mesylate versus ribavirin suggest that insertion of these agents into the nutrient medium of the cultured cells GMK-AH-1 (D) after infection at concentrations of 50, 25, and 100 microg/ml, respectively, is effective in suppressing the reproduction of severe acute respiratory syndrome (SARS) virus. Arbidol and arbidol mesylate were shown to have a direct antiviral effect in early viral replication in the cultured cells. The promising antiviral agent is arbidol mesylate that is nearly 5 times as effective as arbidol in reducing the reproduction of SARS virus in the cultured cells. Insertion of arbidol, arbidol mesylate, and ribavirin into the nutrient medium 2 hours after infection of porcine embryonic renal cells caused a reduction in the accumulation of the pathogen by 2.5, 2.1, and 2.6 Ig, respectively.
AuthorsR A Khamitov, S Ia Loginova, V N Shchukina, S V Borisevich, V A Maksimov, A M Shuster
JournalVoprosy virusologii (Vopr Virusol) 2008 Jul-Aug Vol. 53 Issue 4 Pg. 9-13 ISSN: 0507-4088 [Print] Russia (Federation)
PMID18756809 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antiviral Agents
  • Indoles
  • Ribavirin
  • arbidol
Topics
  • Animals
  • Antiviral Agents (pharmacology)
  • Cell Line
  • Cercopithecus aethiops
  • Dose-Response Relationship, Drug
  • Indoles (pharmacology)
  • Ribavirin (pharmacology)
  • SARS Virus (drug effects, physiology)
  • Virus Replication (drug effects)

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