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Leptin in nonalcoholic fatty liver disease.

AbstractBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition associated with obesity and insulin resistance (IR). Leptin plays a key role in the control of energy balance, and insulin sensitivity. In this study, we aimed to examine whether serum leptin levels correlate with insulin resistance, oxidative stress parameters and the severity of histological changes in NAFLD. METHODS: Fifty-two patients (M/F: 28/24) with no alcohol intake and biopsy-proven diagnosis of NAFLD were studied. Serum leptin levels were measured by radioimmunoassay. HOMA (homeostasis model assessment) IR index was calculated. Comparisons between the patients with NAFLD and non-alcoholic steatohepatitis (NASH) were performed using the Student's t test. Multivariate regression analysis and the area under the receiver operating characteristic (ROC) curve were used to identify the independent predictors for NASH. RESULTS: We found no association between serum leptin, fasting insulin levels, and oxidative stress parameters. ROC curve and multiple regression analysis revealed no association between the severity of histological changes and serum leptin levels. During six months followed-up period only NASH group with elevated leptin levels had significant reductions of ALT and AST values (p = 0.03, and 0.005, respectively). CONCLUSION: Our findings show a preventive effect of leptin against progressive liver injury in NAFLD.
AuthorsBillur Canbakan, Veysel Tahan, Huriye Balci, Ibrahim Hatemi, Burak Erer, Gulsen Ozbay, Necdet Sut, Munire Hacibekiroglu, Nese Imeryuz, Hakan Senturk (Affiliation: Istanbul Science University, Avrupa Florence Nightingale Hospital Research Center, Department of Gastroenterology, Istanbul, Turkey.)
JournalAnnals of hepatology : official journal of the Mexican Association of Hepatology (Ann Hepatol) 2008 Jul-Sep Vol. 7 Issue 3 Pg. 249-54 ISSN: 1665-2681 Mexico
PMID18753993 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Leptin
  • Insulin
Topics
  • Adult
  • Disease Progression
  • Fatty Liver (blood, pathology, physiopathology, prevention & control)
  • Female
  • Humans
  • Insulin (blood)
  • Insulin Resistance
  • Leptin (blood)
  • Liver (metabolism, pathology, physiopathology)
  • Male
  • Middle Aged
  • Oxidative Stress
  • ROC Curve
  • Severity of Illness Index
  • Time Factors