| Abstract | Growing evidence shows that dysfunction of the limbic basal ganglia (BG) network is implicated in repetitive behaviors, such as obsessive compulsive disorder (OCD) and Tourette's syndrome (TS), in humans. Because deep brain stimulation (DBS) of the posterior subthalamic nucleus (STN), which modulates the sensorimotor BG network, is beneficial in movement disorders, stimulation of the anterior, limbic STN might improve intractable behavioral disorders. We therefore evaluated the effect of anterior STN stimulation on the repetitive behaviors induced in two monkeys after bicuculline-induced dysfunction of the limbic external globus pallidus. DBS in the anterior STN dramatically reduced the stereotypies, but had no effect on the performance of a simple food retrieval task. Stimulations outside the STN were less effective in reducing the stereotypies. Electrode trajectories, reconstructed postmortem, confirmed that the effective contacts were in the anterior STN. DBS in the limbic STN might therefore provide relief from the severe stereotyped behaviors observed in OCD and TS. |
| Authors | Nicolas Baup, David Grabli, Carine Karachi, Stéphanie Mounayar, Chantal François, Jérôme Yelnik, Jean Féger, Léon Tremblay
(Affiliation: Département de Psychiatrie, Centre Hospitalier Saint Anne, Paris F-75014, France.)
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| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience
(J Neurosci)
Vol. 28
Issue 35
Pg. 8785-8
(Aug 27 2008)
ISSN: 1529-2401 United States |
| PMID | 18753380
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
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| Topics |
- Animals
- Behavior, Animal
(radiation effects)
- Bicuculline
(toxicity)
- Cercopithecus aethiops
- Convulsants
(toxicity)
- Deep Brain Stimulation
(methods)
- Dose-Response Relationship, Radiation
- Feeding Behavior
(drug effects, radiation effects)
- Globus Pallidus
(drug effects)
- Male
- Movement Disorders
(etiology, physiopathology, therapy)
- Statistics, Nonparametric
- Stereotyped Behavior
(drug effects, radiation effects)
- Subthalamic Nucleus
(physiology, radiation effects)
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