Abstract | BACKGROUND: OBJECTIVES: To summarize the experience of several pediatric gastroenterology units in Israel using a TGFbeta2-enriched polymeric diet (Modulen IBD) supplementation in children and adolescents with Crohn's disease. METHODS: In a retrospective study we reviewed the charts of 28 children with Crohn's disease (10 girls, 18 boys) who received, in addition to conventional treatment, Modulen IBD as a supplement to their regular nutrition. These children were compared with 18 children supplemented with standard polymeric formula ( Ensure Plus) and 18 children without formula supplementation. We recorded clinical manifestations, growth, and the Pediatric Crohn's Disease Activity Index before and after initiation of the polymeric diet. RESULTS: The Modulen-treated children showed a significant decrease in PCDAI from 34.3 to 15.7 (P< 0.0001). A significant decrease in PCDAI was recorded also in the Ensure Plus group, from 35 to 22 (P= 0.02) but not in the non-supplemented group. Significant improvements in body mass index (P = 0.01) and erythrocyte sedimentation rate (P= 0.03) were recorded at follow-up (median 3.4 months) only in the Modulen IBD group. CONCLUSIONS: In this cohort of children with Crohn's disease, supplementation of the diet with Modulen IBD as well as supplementation with Ensure Plus was associated with a decrease in PCDAI. The children supplemented with Modulen IBD also showed improvement in BMI, suggesting an additional advantage of nutritional therapy in children with this disease.
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Authors | Corina Hartman, Drora Berkowitz, Batia Weiss, Ron Shaoul, Arie Levine, Orly Eshach Adiv, Riki Shapira, Akiva Fradkin, Michael Wilschanski, Ada Tamir, Raanan Shamir |
Journal | The Israel Medical Association journal : IMAJ
(Isr Med Assoc J)
Vol. 10
Issue 7
Pg. 503-7
(Jul 2008)
ISSN: 1565-1088 [Print] Israel |
PMID | 18751627
(Publication Type: Journal Article)
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Chemical References |
- Transforming Growth Factor beta2
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Topics |
- Adolescent
- Adult
- Anthropometry
- Body Mass Index
- Child
- Child, Preschool
- Crohn Disease
(diet therapy, physiopathology)
- Diet
- Dietary Supplements
- Female
- Humans
- Male
- Remission Induction
- Retrospective Studies
- Transforming Growth Factor beta2
(therapeutic use)
- Treatment Outcome
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