[Protoscolicidal effect of some chemical agents and drugs against Echinococcus granulosus].

Abstract

The present paper reports the protoscolicidal action of hydrastine, ether-acetic acid-ethanol admixture, H2O2, pyquiton and albendazole through in vitro or in vivo exposure, for 15 minutes and transplantation studies. The mortality of protoscolices in vitro and in vivo were 70.2% and 68.9% for 0.3% hydrastine, 56.8% and 56.2% for 10% ether-acetic acid-ethanol admixture, 6.0% and 8.8% for 0.3% H2O2; 6.1% for 0.004% pyquiton in vitro and 5.0% were 10% and 25% for 0.3% hydrastine, 30% and for 0.004% albendazole in vitro. The survival rates after transplantation of protoscolices 37.5% for 10% ether-acetic acid-ethanol admixture, 100% and 95% for 0.3% H2O2 respectively. Disruption of external plasma membrane, hook detachment, sucker deformity of protoscolices exposed to hydrastine were demonstrated by scanning electron microscopy. It is suggested that hydrastine exerts a profound intracellular effect on the protoscolex of E. granulosus of sheep and man, and might be a promising protoscolicide as adjuvant to hydatid surgery.

• Authors: Q M Chen, Y C Ye, F L Chai, K P Jin
• Journal: Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) Vol. 9 Issue 2 Pg. 137-9 ( 1991) ISSN: 1000-7423 [Print] China
• PMID: 1873887 (Publication Type: English Abstract, Journal Article)

Chemical References

• Acetates
• Alkaloids
• Benzylisoquinolines
• Drugs, Chinese Herbal
• Ether
• Ethanol
• Praziquantel
• hydrastine
• Albendazole

Topics

• Acetates (pharmacology)
• Albendazole (pharmacology)
• Alkaloids (analysis, pharmacology)
• Animals
• Benzylisoquinolines
• Drugs, Chinese Herbal (chemistry)
• Echinococcosis, Hepatic (drug therapy)
• Echinococcus (drug effects, ultrastructure)
• Ethanol (pharmacology)
• Ether (pharmacology)
• Mice
• Praziquantel (pharmacology)